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Costunolide specifically binds and inhibits thioredoxin reductase 1 to induce apoptosis in colon cancer.
Zhuge, Weishan; Chen, Ruijie; Vladimir, Katanaev; Dong, Xidan; Zia, Khan; Sun, Xiangwei; Dai, Xuanxuan; Bao, Miao; Shen, Xian; Liang, Guang.
Afiliação
  • Zhuge W; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
  • Chen R; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
  • Vladimir K; School of Biomedicine, Far Eastern Federal University, Sukhanova Street 8, Vladivostok, 690922, Russian Federation.
  • Dong X; Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
  • Zia K; Department of Pathology and Laboratory Medicine, Western University, London, ON N6A5C1, Canada.
  • Sun X; Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
  • Dai X; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
  • Bao M; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
  • Shen X; Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China. Electronic address: 13968888873
  • Liang G; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China. Electronic address: wzmcliangguang@163.com.
Cancer Lett ; 412: 46-58, 2018 01 01.
Article em En | MEDLINE | ID: mdl-29037867
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sesquiterpenos / Apoptose / Neoplasias do Colo / Tiorredoxina Redutase 1 Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Cancer Lett Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China País de publicação: Irlanda
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sesquiterpenos / Apoptose / Neoplasias do Colo / Tiorredoxina Redutase 1 Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Cancer Lett Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China País de publicação: Irlanda