Glucagon-like peptide receptor agonists attenuate advanced glycation end products-induced inflammation in rat mesangial cells.
BMC Pharmacol Toxicol
; 18(1): 67, 2017 10 24.
Article
em En
| MEDLINE
| ID: mdl-29065926
ABSTRACT
BACKGROUND:
Hyperglycemia-induced advanced glycation end products (AGEs) and receptor for AGEs (RAGE) production play major roles in progression of diabetic nephropathy. Anti-RAGE effect of peroxisome proliferator-activated receptor-delta (PPARδ) agonists was shown in previous studies. PPARδ agonists also stimulate glucagon-like peptide-1 (GLP-1) secretion from human intestinal cells.METHODS:
In this study, the individual and synergic anti-inflammatory effects of GLP-1 receptor (exendin-4) and PPARδ (L-165,041) agonists in AGE-treated rat mesangial cells (RMC) were investigated.RESULTS:
The results showed both exendin-4 and L-165,041 significantly attenuated AGE-induced IL-6 and TNF-α production, RAGE expression, and cell death in RMC. Similar anti-inflammatory potency was seen between 0.3 nM exendin-4 and 1 µM L-165,041. Synergic effect of exendin-4 and L-165,041 was shown in inhibiting cytokines production, but not in inhibiting RAGE expression or cell death.CONCLUSIONS:
These results suggest that both GLP-1 receptor and PPARδ agonists have anti-inflammatory effect on AGE-treated rat mesangial cells.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
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Fenoxiacetatos
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Peçonhas
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Células Mesangiais
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Receptor do Peptídeo Semelhante ao Glucagon 1
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Anti-Inflamatórios
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Antioxidantes
Limite:
Animals
Idioma:
En
Revista:
BMC Pharmacol Toxicol
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Taiwan