Influence of maternal age on the effects of seleno-l-methionine in the model organism Daphnia pulex under standard and heat stress conditions.
Reprod Toxicol
; 75: 1-9, 2018 01.
Article
em En
| MEDLINE
| ID: mdl-29128604
ABSTRACT
Selenium deficiency and toxicity increase the risk of adverse developmental and reproductive outcomes; however, few multi-stressor studies have evaluated the influence of maternal age on organic selenium dose-response and additional stressors over the life course. While multi-stressor research in mammalian models is time-consuming and expensive, use of alternative models can efficiently produce screening data for prioritizing research in mammalian systems. As a well-known eco-toxicological model, Daphnia pulex, may offer advantages in screening for impacts of multi-stressor exposures. We evaluated the influence of maternal age on the effects of seleno-methionine (SeMet) for lifespan, reproduction, and heat-stress resistance in D. pulex. Our results show effects of SeMet-treatment and maternal age, where the highest SeMet-treatment had reduced lifespan and absence of reproduction, and where Daphnia from late life broods had increased resistance to heat-induced stress. Further analysis suggests an additional interactive effect between maternal age and SeMet treatment on time to first reproduction.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Selenometionina
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Idade Materna
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Resposta ao Choque Térmico
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Daphnia
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Longevidade
Limite:
Animals
Idioma:
En
Revista:
Reprod Toxicol
Assunto da revista:
EMBRIOLOGIA
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MEDICINA REPRODUTIVA
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TOXICOLOGIA
Ano de publicação:
2018
Tipo de documento:
Article