Proenkephalin in Heart Failure.
Heart Fail Clin
; 14(1): 1-11, 2018 Jan.
Article
em En
| MEDLINE
| ID: mdl-29153195
ABSTRACT
The opioid system is activated in heart failure, which may be cardioprotective but may also be counter-regulatory. Recently, systemic proenkephalin activation has been investigated in various conditions predicting mortality and kidney injury. In acute heart failure, proenkephalin independently predicts mortality and heart failure rehospitalization in addition to traditional risk markers. It also predicts worsening renal function, increasingly recognized as an important risk predictor for poor outcome in heart failure. This article explores the role of enkephalins and delta-opioid receptors in the heart, then reviews studies measuring proenkephalin levels in the circulation and their associations with prognosis.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Precursores de Proteínas
/
Pressão Sanguínea
/
Encefalinas
/
Receptores Opioides delta
/
Insuficiência Cardíaca
/
Frequência Cardíaca
/
Contração Miocárdica
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Heart Fail Clin
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Reino Unido