An experimental study of ascorbic acid effects in acute renal failure under general anesthesia.
Acta Cir Bras
; 32(10): 853-861, 2017 Oct.
Article
em En
| MEDLINE
| ID: mdl-29160372
ABSTRACT
PURPOSE:
To evaluate the preventive effect of ascorbic acid on sevoflurane-induced acute renal failure in an experimental rat model.METHODS:
Twenty-four adult male Wistar rats were randomly distributed into three groups. Subjects were allocated into 3 groups Group I received sevoflurane only, whereas Groups II and III had moderate (150 mg/kg) and high (300 mg/kg) doses of AA in addition to sevoflurane, respectively. Rhabdomyolysis and myohemoglobinuric ARF was formed by intramuscular administration of glycerol on the upper hind limb on the 15th minute of inhalation anesthesia. Biochemical parameters consisted of serum levels of blood urea nitrogen, creatinine, neutrophil gelatinase-associated lipocalin (NGAL), total antioxidant capacity (TAC), and protein carbonyl content. Histopathological variables were tubular necrosis, fibrin, and cast formation.RESULTS:
NGAL levels were significantly lower in Group III than Group II and Group I. On the other hand, TAC, PCO, urea and creatinine levels were notably higher in Group I compared with Groups II and III. There was a significant difference between 3 groups on frequencies of acute tubular necrosis (p=0.003), fibrin (p<0.001) and cast (p<0.001). Acute tubular necrosis and fibrin formation were more prominent in Group I. Casts were more common in Groups II and III.CONCLUSIONS:
The ascorbic acid serve as a prophylactic agent against renal damage in patients receiving sevoflurane anesthesia and higher doses were associated with more apparent protective effects.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácido Ascórbico
/
Vitaminas
/
Anestésicos Inalatórios
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Injúria Renal Aguda
/
Anestesia Geral
/
Éteres Metílicos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Acta Cir Bras
Ano de publicação:
2017
Tipo de documento:
Article