Your browser doesn't support javascript.
loading
Leptin action in normal and pathological pregnancies.
Pérez-Pérez, Antonio; Toro, Ayelén; Vilariño-García, Teresa; Maymó, Julieta; Guadix, Pilar; Dueñas, José L; Fernández-Sánchez, Manuel; Varone, Cecilia; Sánchez-Margalet, Víctor.
Afiliação
  • Pérez-Pérez A; Department of Medical Biochemistry and Molecular Biology, Virgen Macarena University Hospital, University of Seville, Seville, Spain.
  • Toro A; Laboratory of Placental Molecular Physiology, Department of Biological Chemistry, School of Sciences, University of Buenos Aires, IQUIBICEN-CONICET, Buenos Aires, Argentina.
  • Vilariño-García T; Department of Medical Biochemistry and Molecular Biology, Virgen Macarena University Hospital, University of Seville, Seville, Spain.
  • Maymó J; Laboratory of Placental Molecular Physiology, Department of Biological Chemistry, School of Sciences, University of Buenos Aires, IQUIBICEN-CONICET, Buenos Aires, Argentina.
  • Guadix P; Department of Obstetrics and Gynecology, Virgen Macarena University Hospital, University of Seville, Seville, Spain.
  • Dueñas JL; Department of Obstetrics and Gynecology, Virgen Macarena University Hospital, University of Seville, Seville, Spain.
  • Fernández-Sánchez M; Valencian Infertility Institute (IVI), Seville, Spain.
  • Varone C; Laboratory of Placental Molecular Physiology, Department of Biological Chemistry, School of Sciences, University of Buenos Aires, IQUIBICEN-CONICET, Buenos Aires, Argentina.
  • Sánchez-Margalet V; Department of Medical Biochemistry and Molecular Biology, Virgen Macarena University Hospital, University of Seville, Seville, Spain.
J Cell Mol Med ; 22(2): 716-727, 2018 02.
Article em En | MEDLINE | ID: mdl-29160594
ABSTRACT
Leptin is now considered an important signalling molecule of the reproductive system, as it regulates the production of gonadotrophins, the blastocyst formation and implantation, the normal placentation, as well as the foeto-placental communication. Leptin is a peptide hormone secreted mainly by adipose tissue, and the placenta is the second leptin-producing tissue in humans. Placental leptin is an important cytokine which regulates placental functions in an autocrine or paracrine manner. Leptin seems to play a crucial role during the first stages of pregnancy as it modulates critical processes such as proliferation, protein synthesis, invasion and apoptosis in placental cells. Furthermore, deregulation of leptin levels has been correlated with the pathogenesis of various disorders associated with reproduction and gestation, including polycystic ovary syndrome, recurrent miscarriage, gestational diabetes mellitus, pre-eclampsia and intrauterine growth restriction. Due to the relevant incidence of the mentioned diseases and the importance of leptin, we decided to review the latest information available about leptin action in normal and pathological pregnancies to support the idea of leptin as an important factor and/or predictor of diverse disorders associated with reproduction and pregnancy.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações na Gravidez / Leptina Tipo de estudo: Prognostic_studies Limite: Female / Humans / Pregnancy Idioma: En Revista: J Cell Mol Med Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Espanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações na Gravidez / Leptina Tipo de estudo: Prognostic_studies Limite: Female / Humans / Pregnancy Idioma: En Revista: J Cell Mol Med Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Espanha