Gastrin-releasing peptide attenuates fear memory reconsolidation.
Behav Brain Res
; 347: 255-262, 2018 07 16.
Article
em En
| MEDLINE
| ID: mdl-29191578
ABSTRACT
BACKGROUND:
Gastrin Releasing Peptide (GRP) may play a role in fear learning. The GRP Receptor is expressed in the basolateral amygdala and hippocampus, and central administration of GRP mediates fear learning. The effects of GRP on reconsolidation, however, have been minimally explored. Reconsolidation, the process by which formed memories are rendered labile following recall, provides a window of opportunity for pharmacological intervention. Although evidence suggests the window of opportunity to alter reactivated consolidation memory can be as long as 6â¯h, shorter intervals have not been extensively investigated.METHOD:
Male Sprague-Dawley rats received six 1.0â¯mA continuous footshocks. 24â¯h later, were re-exposed to the context (shock chamber). Immediately following memory retrieval rats received i.p. injection of GRP (10â¯nmol/kg), Flumazenil (1â¯mg/kg), GRPâ¯+â¯Flumazenil (10â¯nmol/kg GRP with 1â¯mg/kg Flumazenil), or Vehicle. Other groups received GRP or Vehicle at 0, 10, 30, or 60â¯min post-reactivation. 24â¯h and 5â¯days later rats were assessed for fear expression upon re-exposure to the fearful stimulus.RESULTS:
GRP significantly attenuated the reconsolidation of learned fear when administered immediately (but not 10â¯min or longer) following recall. Some of the variability in the impact of treatments aimed at disrupting fear memories may be governed, in part, by the time-frame of the reconsolidation window. Our results indicate that the effect of immediate administration persisted for at least 5â¯days. Co-administration of benzodiazepine-receptor antagonist Flumazenil blocked this effect, suggesting the effect is mediated via a GABAergic mechanism.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Psicotrópicos
/
Peptídeo Liberador de Gastrina
/
Medo
/
Consolidação da Memória
Limite:
Animals
Idioma:
En
Revista:
Behav Brain Res
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Canadá