A Schizophrenia-Linked KALRN Coding Variant Alters Neuron Morphology, Protein Function, and Transcript Stability.

Russell, Theron A; Grubisha, Melanie J; Remmers, Christine L; Kang, Seok Kyu; Forrest, Marc P; Smith, Katharine R; Kopeikina, Katherine J; Gao, Ruoqi; Sweet, Robert A; Penzes, Peter

Russell, Theron A; Grubisha, Melanie J; Remmers, Christine L; Kang, Seok Kyu; Forrest, Marc P; Smith, Katharine R; Kopeikina, Katherine J; Gao, Ruoqi; Sweet, Robert A; Penzes, Peter.

Afiliação

Russell TA; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Grubisha MJ; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Remmers CL; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Kang SK; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Forrest MP; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Smith KR; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Kopeikina KJ; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Gao R; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Sweet RA; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; VISN 4 Mental Illness Research, Education and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh,
Penzes P; Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Electronic address: p-penzes@northwestern.edu.

Biol Psychiatry ; 83(6): 499-508, 2018 03 15.

Article em En | MEDLINE | ID: mdl-29241584

Assuntos

Fatores de Troca do Nucleotídeo Guanina/genética; Fatores de Troca do Nucleotídeo Guanina/metabolismo; Neurônios/metabolismo; Neurônios/patologia; Polimorfismo de Nucleotídeo Único/genética; Proteínas Serina-Treonina Quinases/genética; Proteínas Serina-Treonina Quinases/metabolismo; Esquizofrenia; Feminino; Células HEK293; Humanos; Masculino; RNA Mensageiro/metabolismo; Esquizofrenia/genética; Esquizofrenia/metabolismo; Esquizofrenia/patologia; Transfecção

Palavras-chave

Dendrites; Dendritic spines; Guanine nucleotide exchange factors; Kalirin; Schizophrenia; Single nucleotide variants

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia / Proteínas Serina-Treonina Quinases / Fatores de Troca do Nucleotídeo Guanina / Polimorfismo de Nucleotídeo Único / Neurônios Tipo de estudo: Prognostic_studies Limite: Female / Humans / Male Idioma: En Revista: Biol Psychiatry Ano de publicação: 2018 Tipo de documento: Article País de publicação: Estados Unidos

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