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Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling.
Mack, Stephen C; Pajtler, Kristian W; Chavez, Lukas; Okonechnikov, Konstantin; Bertrand, Kelsey C; Wang, Xiuxing; Erkek, Serap; Federation, Alexander; Song, Anne; Lee, Christine; Wang, Xin; McDonald, Laura; Morrow, James J; Saiakhova, Alina; Sin-Chan, Patrick; Wu, Qiulian; Michaelraj, Kulandaimanuvel Antony; Miller, Tyler E; Hubert, Christopher G; Ryzhova, Marina; Garzia, Livia; Donovan, Laura; Dombrowski, Stephen; Factor, Daniel C; Luu, Betty; Valentim, Claudia L L; Gimple, Ryan C; Morton, Andrew; Kim, Leo; Prager, Briana C; Lee, John J Y; Wu, Xiaochong; Zuccaro, Jennifer; Thompson, Yuan; Holgado, Borja L; Reimand, Jüri; Ke, Susan Q; Tropper, Adam; Lai, Sisi; Vijayarajah, Senthuran; Doan, Sylvia; Mahadev, Vaidehi; Miñan, Ana Fernandez; Gröbner, Susanne N; Lienhard, Matthias; Zapatka, Marc; Huang, Zhiqin; Aldape, Kenneth D; Carcaboso, Angel M; Houghton, Peter J.
Afiliação
  • Mack SC; Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
  • Pajtler KW; Department of Pediatric Hematolgy and Oncology, Texas Children's Cancer and Hematology Centers, Houston, Texas, USA.
  • Chavez L; Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
  • Okonechnikov K; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio 44195, USA.
  • Bertrand KC; Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), 69120 Heidelberg, Germany.
  • Wang X; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.
  • Erkek S; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, 69120 Heidelberg, Germany.
  • Federation A; Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), 69120 Heidelberg, Germany.
  • Song A; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.
  • Lee C; Department of Medicine, Division of Medical Genetics, University of California - San Diego School of Medicine, La Jolla, California 92093, USA.
  • Wang X; Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), 69120 Heidelberg, Germany.
  • McDonald L; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.
  • Morrow JJ; Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
  • Saiakhova A; Department of Pediatric Hematolgy and Oncology, Texas Children's Cancer and Hematology Centers, Houston, Texas, USA.
  • Sin-Chan P; Department of Pediatrics, Cleveland Clinic, Cleveland, Ohio 44195, USA.
  • Wu Q; Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
  • Michaelraj KA; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio 44195, USA.
  • Miller TE; Department of Medicine, Division of Regenerative Medicine, University of California - San Diego School of Medicine, La Jolla, California, USA.
  • Hubert CG; Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), 69120 Heidelberg, Germany.
  • Ryzhova M; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.
  • Garzia L; European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany.
  • Donovan L; Department of Genomic Sciences, University of Washington, Seattle, Washington 355065, USA.
  • Dombrowski S; Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
  • Factor DC; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio 44195, USA.
  • Luu B; Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
  • Valentim CLL; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio 44195, USA.
  • Gimple RC; Division of Neurosurgery, Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
  • Morton A; Division of Neurosurgery, Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
  • Kim L; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio 44106, USA.
  • Prager BC; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio 44106, USA.
  • Lee JJY; Division of Neurosurgery, Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
  • Wu X; Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
  • Zuccaro J; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio 44195, USA.
  • Thompson Y; Department of Medicine, Division of Regenerative Medicine, University of California - San Diego School of Medicine, La Jolla, California, USA.
  • Holgado BL; Division of Neurosurgery, Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
  • Reimand J; Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
  • Ke SQ; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio 44195, USA.
  • Tropper A; Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA.
  • Lai S; Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
  • Vijayarajah S; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio 44195, USA.
  • Doan S; Department of Neuropathology, NN Burdenko Neurosurgical Institute, 4th Tverskaya-Yamskaya 16, Moscow 125047, Russia.
  • Mahadev V; Division of Neurosurgery, Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
  • Miñan AF; Division of Neurosurgery, Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
  • Gröbner SN; Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
  • Lienhard M; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio 44195, USA.
  • Zapatka M; Rose Ella Burkhardt Brain Tumor & Neuro-Oncology Center, Cleveland Clinic Neurological Institute, Department of Neurosurgery, Cleveland Clinic, Cleveland, Ohio 44195, USA.
  • Huang Z; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio 44106, USA.
  • Aldape KD; Division of Neurosurgery, Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
  • Carcaboso AM; Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
  • Houghton PJ; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio 44195, USA.
Nature ; 553(7686): 101-105, 2018 01 04.
Article em En | MEDLINE | ID: mdl-29258295
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oncogenes / Fatores de Transcrição / Regulação Neoplásica da Expressão Gênica / Elementos Facilitadores Genéticos / Ependimoma / Redes Reguladoras de Genes / Terapia de Alvo Molecular Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Nature Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oncogenes / Fatores de Transcrição / Regulação Neoplásica da Expressão Gênica / Elementos Facilitadores Genéticos / Ependimoma / Redes Reguladoras de Genes / Terapia de Alvo Molecular Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Nature Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido