Immune-mediated thrombocytopenia and hypothyroidism in a lung cancer patient treated with nivolumab.
Immunotherapy
; 10(2): 85-91, 2018 02.
Article
em En
| MEDLINE
| ID: mdl-29260625
Patients treated with immune checkpoint inhibitors can develop various immunological complications; however, few cases of immune thrombocytopenia occurring in association with the administration of these agents have so far been reported. We herein report the case of a 62-year-old Japanese man with non-small-cell lung cancer who developed immune thrombocytopenia and hypothyroidism during nivolumab therapy. After the second administration of the drug, his peripheral blood platelet count rapidly decreased to 1.6 × 104/µl with a petechial rash and symptoms associated with a low thyroid function. Nivolumab-induced immune thrombocytopenia and hypothyroidism were suspected based on the presence of platelet-associated IgG, an increased level of autoantibodies to thyroglobulin and thyroid peroxidase and an enlarged thyroid gland. The patient eventually made a full recovery after treatment with oral prednisolone and levothyroxine. Further investigations and the accumulation of data are necessary to elucidate the precise mechanisms underlying the autoimmune responses that occur in patients treated with immune checkpoint inhibitors.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glândula Tireoide
/
Plaquetas
/
Púrpura Trombocitopênica Idiopática
/
Carcinoma Pulmonar de Células não Pequenas
/
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
/
Hipotireoidismo
/
Imunoterapia
/
Neoplasias Pulmonares
/
Anticorpos Monoclonais
/
Antineoplásicos
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
/
Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Immunotherapy
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
TERAPEUTICA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Japão
País de publicação:
Reino Unido