Interaction of Aß1-42 peptide or their variant with model membrane of different composition probed by infrared nanospectroscopy.
Nanoscale
; 10(3): 936-940, 2018 Jan 18.
Article
em En
| MEDLINE
| ID: mdl-29292465
ABSTRACT
Toxicity of Aß peptides involved in Alzheimer's disease is linked to the interaction of intermediate species with membranes. Nanoscale Infrared Spectroscopy enhances the study of the morphology and the secondary structure of the peptides as fibers or oligomers interacting with membranes of different compositions, with nanometer scale resolution. Membrane models are used to investigate the role of different lipids in their interactions with Aß peptides. This work clearly brings to light that the presence of cholesterol in membranes is favorable to the interaction with Aß peptides in oligomers or aggregates.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Membrana Celular
/
Colesterol
/
Peptídeos beta-Amiloides
Limite:
Humans
Idioma:
En
Revista:
Nanoscale
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
França