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The novel brassinosteroid analog BR4848 inhibits angiogenesis in human endothelial cells and induces apoptosis in human cancer cells in vitro.
Rárová, Lucie; Sedlák, David; Oklestkova, Jana; Steigerová, Jana; Liebl, Johanna; Zahler, Stefan; Bartunek, Petr; Kolár, Zdenek; Kohout, Ladislav; Kvasnica, Miroslav; Strnad, Miroslav.
Afiliação
  • Rárová L; Department of Chemical Biology and Genetics, Centre of the Region Haná for Biotechnological and Agricultural Research, Faculty of Science, Palacký University, Slechtitelu 27, 783 71, Olomouc, Czech Republic. Electronic address: lucie.rarova@upol.cz.
  • Sedlák D; CZ-OPENSCREEN: National Infrastructure for Chemical Biology, Institute of Molecular Genetics Academy of Sciences of the Czech Republic, Vídenská 1083, 142 20, Praha 4, Czech Republic. Electronic address: sedlak@img.cas.cz.
  • Oklestkova J; Laboratory of Growth Regulators, Institute of Experimental Botany ASCR & Palacký University, Slechtitelu 27, 78371, Olomouc, Czech Republic.
  • Steigerová J; Laboratory of Molecular Pathology, Department of Clinical and Molecular Pathology, Faculty of Medicine, Palacký University, Hnevotínská 5, 77900, Olomouc, Czech Republic; Institute of Molecular and Translation Medicine, Faculty of Medicine and Dentistry, Palacký University and Faculty Hospital in Ol
  • Liebl J; Department of Pharmacy, LMU Munich - Center for Drug Research - Pharmaceutical Biology, Butenandtstr. 5-13, Munich, 81377, Germany.
  • Zahler S; Department of Pharmacy, LMU Munich - Center for Drug Research - Pharmaceutical Biology, Butenandtstr. 5-13, Munich, 81377, Germany.
  • Bartunek P; CZ-OPENSCREEN: National Infrastructure for Chemical Biology, Institute of Molecular Genetics Academy of Sciences of the Czech Republic, Vídenská 1083, 142 20, Praha 4, Czech Republic.
  • Kolár Z; Laboratory of Molecular Pathology, Department of Clinical and Molecular Pathology, Faculty of Medicine, Palacký University, Hnevotínská 5, 77900, Olomouc, Czech Republic; Institute of Molecular and Translation Medicine, Faculty of Medicine and Dentistry, Palacký University and Faculty Hospital in Ol
  • Kohout L; Laboratory of Growth Regulators, Institute of Experimental Botany ASCR & Palacký University, Slechtitelu 27, 78371, Olomouc, Czech Republic.
  • Kvasnica M; Laboratory of Growth Regulators, Institute of Experimental Botany ASCR & Palacký University, Slechtitelu 27, 78371, Olomouc, Czech Republic.
  • Strnad M; Laboratory of Growth Regulators, Institute of Experimental Botany ASCR & Palacký University, Slechtitelu 27, 78371, Olomouc, Czech Republic.
J Steroid Biochem Mol Biol ; 178: 263-271, 2018 04.
Article em En | MEDLINE | ID: mdl-29307714
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apoptose / Inibidores da Angiogênese / Células Endoteliais da Veia Umbilical Humana / Brassinosteroides / Neoplasias / Neovascularização Patológica Limite: Humans Idioma: En Revista: J Steroid Biochem Mol Biol Assunto da revista: BIOLOGIA MOLECULAR / BIOQUIMICA Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apoptose / Inibidores da Angiogênese / Células Endoteliais da Veia Umbilical Humana / Brassinosteroides / Neoplasias / Neovascularização Patológica Limite: Humans Idioma: En Revista: J Steroid Biochem Mol Biol Assunto da revista: BIOLOGIA MOLECULAR / BIOQUIMICA Ano de publicação: 2018 Tipo de documento: Article