Cryopyrin-associated periodic syndrome in early childhood can be successfully treated with interleukin-1 blockades.
Acta Paediatr
; 107(4): 577-580, 2018 Apr.
Article
em En
| MEDLINE
| ID: mdl-29331074
ABSTRACT
Cryopyrin-associated periodic syndrome (CAPS) is caused by a mutation in the NLRP3 gene encoding cryopyrin production. Overproduction of interleukin-1 (IL-1) leads to symptoms that are associated with elevated inflammatory markers, including periodic fever and a rash. We provide a clinical overview of CAPS in children, including three Finnish case studies. CONCLUSION:
When CAPS has been diagnosed, an IL-1 blockade with biological should be introduced to lessen the symptoms and to prevent the progression of organ damage.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Interleucina-1
/
Síndromes Periódicas Associadas à Criopirina
Tipo de estudo:
Diagnostic_studies
/
Risk_factors_studies
Limite:
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Idioma:
En
Revista:
Acta Paediatr
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Finlândia