HIV Immunogens: Affinity Is Key.

Prabhu, Savit; Cockburn, Ian A; Vinuesa, Carola G

Prabhu, Savit; Cockburn, Ian A; Vinuesa, Carola G.

Afiliação

Prabhu S; Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, Australian National University, Canberra, Australia.
Cockburn IA; Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, Australian National University, Canberra, Australia.
Vinuesa CG; Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, Australian National University, Canberra, Australia. Electronic address: carola.vinuesa@anu.edu.au.

Immunity ; 48(1): 11-13, 2018 01 16.

Article em En | MEDLINE | ID: mdl-29343432

ABSTRACT

ABSTRACT

Generation of broadly neutralizing antibodies is a key aim of HIV vaccine design, but the precursor B cells are rare. Abbott et al. (2018) report that high affinity and avidity immunogens are required to promote maturation of low frequency B cells in germinal centers.

Assuntos

Anticorpos Anti-HIV; HIV-1/imunologia; Vacinas contra a AIDS; Anticorpos Neutralizantes; Infecções por HIV; Humanos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anticorpos Anti-HIV / HIV-1 Limite: Humans Idioma: En Revista: Immunity Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Austrália País de publicação: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA

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