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A chelicerate-specific burst of nonclassical Dscam diversity.
Cao, Guozheng; Shi, Yang; Zhang, Jian; Ma, Hongru; Hou, Shouqing; Dong, Haiyang; Hong, Weiling; Chen, Shuo; Li, Hao; Wu, Yandan; Guo, Pengjuan; Shao, Xu; Xu, Bingbing; Shi, Feng; Meng, Yijun; Jin, Yongfeng.
Afiliação
  • Cao G; Zhejiang University, Institute of Biochemistry, College of Life Sciences, Hangzhou, Zhejiang, ZJ310058, People's Republic of China.
  • Shi Y; Zhejiang University, Institute of Biochemistry, College of Life Sciences, Hangzhou, Zhejiang, ZJ310058, People's Republic of China.
  • Zhang J; Zhejiang University, Institute of Biochemistry, College of Life Sciences, Hangzhou, Zhejiang, ZJ310058, People's Republic of China.
  • Ma H; Zhejiang University, Institute of Biochemistry, College of Life Sciences, Hangzhou, Zhejiang, ZJ310058, People's Republic of China.
  • Hou S; Zhejiang University, Institute of Biochemistry, College of Life Sciences, Hangzhou, Zhejiang, ZJ310058, People's Republic of China.
  • Dong H; Zhejiang University, Institute of Biochemistry, College of Life Sciences, Hangzhou, Zhejiang, ZJ310058, People's Republic of China.
  • Hong W; Zhejiang University, Institute of Biochemistry, College of Life Sciences, Hangzhou, Zhejiang, ZJ310058, People's Republic of China.
  • Chen S; Zhejiang University, Institute of Biochemistry, College of Life Sciences, Hangzhou, Zhejiang, ZJ310058, People's Republic of China.
  • Li H; Zhejiang University, Institute of Biochemistry, College of Life Sciences, Hangzhou, Zhejiang, ZJ310058, People's Republic of China.
  • Wu Y; Zhejiang University, Institute of Biochemistry, College of Life Sciences, Hangzhou, Zhejiang, ZJ310058, People's Republic of China.
  • Guo P; Zhejiang University, Institute of Biochemistry, College of Life Sciences, Hangzhou, Zhejiang, ZJ310058, People's Republic of China.
  • Shao X; Zhejiang University, Institute of Biochemistry, College of Life Sciences, Hangzhou, Zhejiang, ZJ310058, People's Republic of China.
  • Xu B; Zhejiang University, Institute of Biochemistry, College of Life Sciences, Hangzhou, Zhejiang, ZJ310058, People's Republic of China.
  • Shi F; Zhejiang University, Institute of Biochemistry, College of Life Sciences, Hangzhou, Zhejiang, ZJ310058, People's Republic of China.
  • Meng Y; College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, ZJ310018, People's Republic of China.
  • Jin Y; Zhejiang University, Institute of Biochemistry, College of Life Sciences, Hangzhou, Zhejiang, ZJ310058, People's Republic of China. jinyf@zju.edu.cn.
BMC Genomics ; 19(1): 66, 2018 01 19.
Article em En | MEDLINE | ID: mdl-29351731
ABSTRACT

BACKGROUND:

The immunoglobulin (Ig) superfamily receptor Down syndrome cell adhesion molecule (Dscam) gene can generate tens of thousands of isoforms via alternative splicing, which is essential for both nervous and immune systems in insects. However, further information is required to develop a comprehensive view of Dscam diversification across the broad spectrum of Chelicerata clades, a basal branch of arthropods and the second largest group of terrestrial animals.

RESULTS:

In this study, a genome-wide comprehensive analysis of Dscam genes across Chelicerata species revealed a burst of nonclassical Dscams, categorised into four types-mDscam, sDscamα, sDscamß, and sDscamγ-based on their size and structure. Although the mDscam gene class includes the highest number of Dscam genes, the sDscam genes utilise alternative promoters to expand protein diversity. Furthermore, we indicated that the 5' cassette duplicate is inversely correlated with the sDscam gene duplicate. We showed differential and sDscam- biased expression of nonclassical Dscam isoforms. Thus, the Dscam isoform repertoire across Chelicerata is entirely dominated by the number and expression levels of nonclassical Dscams. Taken together, these data show that Chelicerata evolved a large conserved and lineage-specific repertoire of nonclassical Dscams.

CONCLUSIONS:

This study showed that arthropods have a large diversified Chelicerata-specific repertoire of nonclassical Dscam isoforms, which are structurally and mechanistically distinct from those of insects. These findings provide a global framework for the evolution of Dscam diversity in arthropods and offer mechanistic insights into the diversification of the clade-specific Ig superfamily repertoire.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrópodes / Moléculas de Adesão Celular / Proteínas de Artrópodes Limite: Animals Idioma: En Revista: BMC Genomics Assunto da revista: GENETICA Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrópodes / Moléculas de Adesão Celular / Proteínas de Artrópodes Limite: Animals Idioma: En Revista: BMC Genomics Assunto da revista: GENETICA Ano de publicação: 2018 Tipo de documento: Article