Physiology of the lung in idiopathic pulmonary fibrosis.
Eur Respir Rev
; 27(147)2018 Mar 31.
Article
em En
| MEDLINE
| ID: mdl-29367408
ABSTRACT
The clinical expression of idiopathic pulmonary fibrosis (IPF) is directly related to multiple alterations in lung function. These alterations derive from a complex disease process affecting all compartments of the lower respiratory system, from the conducting airways to the lung vasculature. In this article we review the profound alterations in lung mechanics (reduced lung compliance and lung volumes), pulmonary gas exchange (reduced diffusing capacity, increased dead space ventilation, chronic arterial hypoxaemia) and airway physiology (increased cough reflex and increased airway volume), as well as pulmonary haemodynamics related to IPF. The relative contribution of these alterations to exertional limitation and dyspnoea in IPF is discussed.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Mecânica Respiratória
/
Ventilação Pulmonar
/
Fibrose Pulmonar Idiopática
/
Pulmão
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Eur Respir Rev
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
França