Acute graft-versus-host disease following lung transplantation in a patient with a novel TERT mutation.
Thorax
; 73(5): 489-492, 2018 05.
Article
em En
| MEDLINE
| ID: mdl-29382801
ABSTRACT
Familial pulmonary fibrosis is associated with loss-of-function mutations in telomerase reverse transcriptase (TERT) and short telomeres. Interstitial lung diseases have become the leading indication for lung transplantation in the USA, and recent data indicate that pathogenic mutations in telomerase may cause unfavourable outcomes following lung transplantation. Although a rare occurrence, solid organ transplant recipients who develop acute graft-versus-host disease (GVHD) have very poor survival. This case report describes the detection of a novel mutation in TERT in a patient who had lung transplantation for familial pulmonary fibrosis and died from complications of acute GVHD.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fibrose Pulmonar
/
Transplante de Pulmão
/
Telomerase
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Doença Enxerto-Hospedeiro
Limite:
Female
/
Humans
Idioma:
En
Revista:
Thorax
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Estados Unidos