Could istradefylline be a treatment option for postural abnormalities in mid-stage Parkinson's disease?
J Neurol Sci
; 385: 131-133, 2018 02 15.
Article
em En
| MEDLINE
| ID: mdl-29406892
ABSTRACT
BASEGROUND Postural abnormalities are refractory complications observed in mid- to late-stage Parkinson's disease (PD). METHODS:
We analyzed the effects of istradefylline, a selective adenosine A2A receptor antagonist, on posture in 21 levodopa-treated PD patients from the subanalysis of a three-month open-label study.RESULTS:
The subitem score of posture (3.13) on the Movement Disorder Society revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) part III significantly improved following istradefylline treatment (baseline, 1.3±1.0 points vs 3months, 0.9±0.9 points; p<0.05). Among 18 patients who had postural abnormalities at baseline, defined as 1 point or greater on MDS-UPDRS part III subitem 3.13, posture improved in 9 (50%) and was unchanged in 9 (50%) patients after istradefylline treatment. Improved and unchanged groups did not show differences in baseline characteristics, except for tendency for a higher rate of Hoehn and Yahr stage IV and V (Off state) observed in the improved group. Changes in scores of posture (3.13) did not correlate with those of other MDS-UPDRS part III items, PD Questionnaire-8, PD Sleep Scale-2 and Epworth Sleepiness Scale.CONCLUSION:
Based on our preliminary findings, istradefylline could be an effective treatment option for postural abnormalities in mid-stage PD patients.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Purinas
/
Transtornos de Sensação
/
Equilíbrio Postural
/
Antagonistas do Receptor A2 de Adenosina
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Neurol Sci
Ano de publicação:
2018
Tipo de documento:
Article