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Low, but not high, dose triptolide controls neuroinflammation and improves behavioral deficits in toxic model of multiple sclerosis by dampening of NF-κB activation and acceleration of intrinsic myelin repair.
Sanadgol, Nima; Golab, Fereshteh; Mostafaie, Ali; Mehdizadeh, Mehdi; Khalseh, Roghayeh; Mahmoudi, Morteza; Abdollahi, Mohammad; Vakilzadeh, Gelareh; Taghizadeh, Ghorban; Sharifzadeh, Mohammad.
Afiliação
  • Sanadgol N; Department of Biology, Faculty of Sciences, University of Zabol, Zabol, Iran; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
  • Golab F; Cellular and Molecular Research Center, Iran University of Medical Science, Tehran, Iran.
  • Mostafaie A; Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Mehdizadeh M; Cellular and Molecular Research Center, Iran University of Medical Science, Tehran, Iran; Faculty of Advanced Technologies in Medicine, Department of Anatomical Sciences, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Khalseh R; Department of Chemical Engineering, Babol Noshirvani University of Technology, Babol, Iran.
  • Mahmoudi M; Department of Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, CA, USA.
  • Abdollahi M; Toxicology and Diseases Group, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Vakilzadeh G; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
  • Taghizadeh G; Department of Occupational Therapy, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran; Rehabilitation Research Center, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran.
  • Sharifzadeh M; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: msharifzadeh@sina.tums.ac.ir.
Toxicol Appl Pharmacol ; 342: 86-98, 2018 03 01.
Article em En | MEDLINE | ID: mdl-29407366
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenantrenos / NF-kappa B / Fármacos Neuroprotetores / Transtornos das Habilidades Motoras / Diterpenos / Esclerose Múltipla / Bainha de Mielina Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Toxicol Appl Pharmacol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Irã País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenantrenos / NF-kappa B / Fármacos Neuroprotetores / Transtornos das Habilidades Motoras / Diterpenos / Esclerose Múltipla / Bainha de Mielina Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Toxicol Appl Pharmacol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Irã País de publicação: Estados Unidos