Gene therapy mediated seizure suppression in Genetic Generalised Epilepsy: Neuropeptide Y overexpression in a rat model.

Powell, Kim L; Fitzgerald, Xavier; Shallue, Claire; Jovanovska, Valentina; Klugmann, Matthias; Von Jonquieres, Georg; O'Brien, Terence J; Morris, Margaret J

Powell, Kim L; Fitzgerald, Xavier; Shallue, Claire; Jovanovska, Valentina; Klugmann, Matthias; Von Jonquieres, Georg; O'Brien, Terence J; Morris, Margaret J.

Afiliação

Powell KL; The Department of Medicine, The University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia; The Department of Neuroscience, The Central Clinical School, Monash University, Melbourne, Victoria, Australia. Electronic address: kim.powell@monash.edu.
Fitzgerald X; The Department of Medicine, The University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Shallue C; The Department of Medicine, The University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Jovanovska V; The Department of Medicine, The University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Klugmann M; School of Medical Sciences, UNSW Sydney, Australia.
Von Jonquieres G; School of Medical Sciences, UNSW Sydney, Australia.
O'Brien TJ; The Department of Medicine, The University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia; The Department of Neuroscience, The Central Clinical School, Monash University, Melbourne, Victoria, Australia.
Morris MJ; School of Medical Sciences, UNSW Sydney, Australia. Electronic address: m.morris@unsw.edu.au.

Neurobiol Dis ; 113: 23-32, 2018 05.

Article em En | MEDLINE | ID: mdl-29414380

Assuntos

Epilepsia Generalizada/metabolismo; Epilepsia Generalizada/terapia; Terapia Genética/métodos; Neuropeptídeo Y/biossíntese; Convulsões/metabolismo; Convulsões/terapia; Animais; Modelos Animais de Doenças; Epilepsia Generalizada/genética; Expressão Gênica; Masculino; Neuropeptídeo Y/genética; Ratos; Ratos Transgênicos; Convulsões/genética

Palavras-chave

Adeno-associated viral vector; Gene therapy; Genetic Generalised Epilepsy; Neuropeptide Y

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Convulsões / Neuropeptídeo Y / Terapia Genética / Epilepsia Generalizada Limite: Animals Idioma: En Revista: Neurobiol Dis Assunto da revista: NEUROLOGIA Ano de publicação: 2018 Tipo de documento: Article País de publicação: Estados Unidos

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