Symptomatic and Functional Recovery From Major Depressive Disorder in the Ibadan Study of Ageing.
Am J Geriatr Psychiatry
; 26(6): 657-666, 2018 06.
Article
em En
| MEDLINE
| ID: mdl-29426606
ABSTRACT
OBJECTIVES:
Very little is known about the association between symptomatic and functional recovery from late-life major depressive disorder (MDD) in sub-Saharan Africa. We investigated factors associated with sustained symptomatic remission (SR) from MDD and the 5-year trajectory of post-MDD physical functioning.DESIGN:
5-year prospective study with three follow-up waves in 2007, 2008, and 2009. SETTING/PARTICIPANTS:
Household multistage probability sample of 2,149 Nigerians who were aged 65 years or older. MEASUREMENTS Activities of Daily Living (ADL) and MDD were assessed using the Kadz index and Composite International Diagnostic Interview, respectively. We studied those with current MDD (prevalent in 2003-2004 or incident in 2007), and who achieved SR in subsequent waves compared with a chronic/recurrent course (CR).RESULTS:
Baseline demographic characteristics, health, and lifestyle factors were not associated with SR in logistic regression analyses. In mixed-effect linear regression models adjusting for age, sex, and socioeconomic status, ADL worsened in SR (ß = 1.0, 95% CI 0.2, 1.8), but more so in CR (ß = 2.3, 95% CI 1.6, 3.0). Poorer ADL at follow-up was predicted by age (ß = 2.9, 95% CI 1.8, 4.0) and economic status (ß = 1.4, 95% CI 0.3, 2.4).CONCLUSIONS:
There was a deteriorating course of disability despite symptomatic recovery from late-life MDD in this sample. This finding has implications for policy and guidelines for the management of late-life depression and disability.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Transtorno Depressivo Maior
Tipo de estudo:
Diagnostic_studies
/
Guideline
/
Observational_studies
/
Prognostic_studies
/
Qualitative_research
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
País/Região como assunto:
Africa
Idioma:
En
Revista:
Am J Geriatr Psychiatry
Assunto da revista:
GERIATRIA
/
PSIQUIATRIA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Nigéria