A cross-omics approach to investigate temporal gene expression regulation by 5-hydroxymethylcytosine via TBH-derived oxidative stress showed involvement of different regulatory kinases.

Briedé, Jacob J; Deferme, Lize; Wolters, Jarno E J; Claessen, Sandra M H; van den Beucken, Twan; Wagner, Richard J; van Breda, Simone G; Kleinjans, Jos C S

Briedé, Jacob J; Deferme, Lize; Wolters, Jarno E J; Claessen, Sandra M H; van den Beucken, Twan; Wagner, Richard J; van Breda, Simone G; Kleinjans, Jos C S.

Afiliação

Briedé JJ; Department of Toxicogenomics, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, P.O. Box 616, 6200, MD, Maastricht, The Netherlands. Electronic address: j.briede@maastrichtuniversity.nl.
Deferme L; Department of Toxicogenomics, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, P.O. Box 616, 6200, MD, Maastricht, The Netherlands; ExxonMobil Petroleum and Chemical, Hermeslaan 2, 1831 Machelen, Belgium.
Wolters JEJ; Department of Toxicogenomics, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, P.O. Box 616, 6200, MD, Maastricht, The Netherlands.
Claessen SMH; Department of Toxicogenomics, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, P.O. Box 616, 6200, MD, Maastricht, The Netherlands.
van den Beucken T; Department of Toxicogenomics, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, P.O. Box 616, 6200, MD, Maastricht, The Netherlands.
Wagner RJ; Département de médecine nucléaire et radiobiologie, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, J1H 5N4 Québec, Canada.
van Breda SG; Department of Toxicogenomics, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, P.O. Box 616, 6200, MD, Maastricht, The Netherlands.
Kleinjans JCS; Department of Toxicogenomics, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, P.O. Box 616, 6200, MD, Maastricht, The Netherlands.

Toxicol In Vitro ; 48: 318-328, 2018 Apr.

Article em En | MEDLINE | ID: mdl-29432895

Assuntos

5-Metilcitosina/análogos & derivados; Regulação da Expressão Gênica/efeitos dos fármacos; Genômica/métodos; Estresse Oxidativo/efeitos dos fármacos; Proteínas Quinases/metabolismo; terc-Butil Hidroperóxido/toxicidade; 5-Metilcitosina/toxicidade; Animais; Redes Reguladoras de Genes/efeitos dos fármacos; Células Hep G2; Humanos; Neoplasias Hepáticas Experimentais/induzido quimicamente; Neoplasias Hepáticas Experimentais/genética; Neoplasias Hepáticas Experimentais/patologia; Metaboloma; Análise em Microsséries; Proteínas Quinases/genética; RNA/genética; RNA/isolamento & purificação

Palavras-chave

5-Hydroxymethylcytosine; 5-Methylcytosine; Differentially expressed genes; HepG2 cells; Serine-threonine kinases; tert-Butyl hydroperoxide

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Quinases / Regulação da Expressão Gênica / Estresse Oxidativo / Terc-Butil Hidroperóxido / Genômica / 5-Metilcitosina Limite: Animals / Humans Idioma: En Revista: Toxicol In Vitro Assunto da revista: TOXICOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de publicação: Reino Unido

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