Soliseptide A, A Cyclic Hexapeptide Possessing Piperazic Acid Groups from Streptomyces solisilvae HNM30702.

Wang, Junfeng; Cong, Ziwen; Huang, Xiaolong; Hou, Chenxi; Chen, Weihao; Tu, Zhengchao; Huang, Dongyi; Liu, Yonghong

Wang, Junfeng; Cong, Ziwen; Huang, Xiaolong; Hou, Chenxi; Chen, Weihao; Tu, Zhengchao; Huang, Dongyi; Liu, Yonghong.

Afiliação

Wang J; CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences , Guangzhou 510301, People's Republic of China.
Cong Z; CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences , Guangzhou 510301, People's Republic of China.
Huang X; Institute of Tropical Agriculture and Forestry, Hainan University , Haikou 570228, People's Republic of China.
Hou C; Institute of Tropical Agriculture and Forestry, Hainan University , Haikou 570228, People's Republic of China.
Chen W; CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences , Guangzhou 510301, People's Republic of China.
Tu Z; CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences , Guangzhou 510301, People's Republic of China.
Huang D; University of Chinese Academy of Sciences , Beijing 100049, People's Republic of China.
Liu Y; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , Guangzhou 510530, People's Republic of China.

Org Lett ; 20(5): 1371-1374, 2018 03 02.

Article em En | MEDLINE | ID: mdl-29441782

ABSTRACT

ABSTRACT

Soliseptide A (1), a cyclic hexapeptide possessing piperazic acid groups, together with two known azalomycin derivatives (2 and 3) were isolated from Streptomyces solisilvae HNM30702. Their structures were determined through spectroscopic methods and single crystal X-ray diffraction analysis. Soliseptide A (1) possessed a cyclic hexapeptide core featured with two piperazic acid units rarely discovered in nature, and exhibited weak antibacterial and antiviral activities. Besides, compounds 2 and 3 displayed significant fungicidal effects.

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Org Lett Assunto da revista: BIOQUIMICA Ano de publicação: 2018 Tipo de documento: Article

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