Predictive effect of hyperuricemia on left atrial stasis in non-valvular atrial fibrillation patients.
Int J Cardiol
; 258: 103-108, 2018 05 01.
Article
em En
| MEDLINE
| ID: mdl-29467096
ABSTRACT
OBJECTIVES:
To investigate the relationship between hyperuricemia and left atrial thrombus (LAT)/spontaneous echo contrast (SEC) and to determine the predictive value of hyperuricemia in non-valvular (NV) atrial fibrillation (AF) patients.METHODS:
The study retrospectively reviewed 1198 consecutive patients (male 801, female 397, and mean age of 56.84⯱â¯12.22) who were diagnosed with AF and accepted transesophageal echocardiography (TEE) prior to catheter ablation, appendage occlusion and electrical cardioversion using a single-center database. The clinical baseline characteristics were collected from medical record review and analyzed. Patients were categorized into an LAT/SEC group and a normal group.RESULTS:
According to the TEE examination, there were 97 (8.1%) patients with abnormality; of these, 49 were with LAT and 48 with SEC. The mean serum uric acid (SUA) level and hyperuricemia proportion were markedly higher in patients with LAT/SEC. The significant predictive effect was observed in the SUA level (ORâ¯=â¯1.006) and hyperuricemia (ORâ¯=â¯2.04). After adjustment for persistent/permanent-AF, age, gender, LA dimensionâ¯>â¯40â¯mm, previous stroke, hypertension and diabetes, the SUA level (ORâ¯=â¯1.004) and hyperuricemia (ORâ¯=â¯1.69) were independent predictors for LAT/SEC. The SUA level (ORâ¯=â¯1.004) and hyperuricemia (ORâ¯=â¯1.69) were independent predictors for LAT/SEC, Further subgroup analysis in different CHA2DS2-VASc categories, it might be helpful to refine the LAT/SEC risk via combination area CHA2DS2-VASc score and hyperuricemia, especially in those with CHA2DS2-VASc scoreâ¯<â¯2.CONCLUSIONS:
The SUA level and hyperuricemia proportion are closely associated with LA stasis. Hyperuricemia might independently predict and refine LA stasis risk among NVAF patients, especially in those with CHA2DS2-VASc scoreâ¯<â¯2.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fibrilação Atrial
/
Hiperuricemia
/
Átrios do Coração
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Int J Cardiol
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
China