Epigenetic regulation of Fgf1 transcription by CRTC1 and memory enhancement.
Brain Res Bull
; 141: 3-12, 2018 07.
Article
em En
| MEDLINE
| ID: mdl-29477835
ABSTRACT
Recent evidence demonstrates that epigenetic regulation of gene transcription is critically involved in learning and memory. Here, we discuss the role of histone acetylation and DNA methylation, which are two best understood epigenetic processes in memory processes. More specifically, we focus on learning-strength-dependent changes in chromatin on the fibroblast growth factor 1 (Fgf1) gene and on the molecular events that modulate regulation of Fgf1 transcription, required for memory enhancement, with the specific focus on CREB-regulated transcription coactivator 1 (CRTC1).
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Fator 1 de Crescimento de Fibroblastos
/
Epigênese Genética
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Memória
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Brain Res Bull
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Japão