Imaging biomarkers of outcome after radiotherapy for pediatric ependymoma.
Radiother Oncol
; 127(1): 103-107, 2018 04.
Article
em En
| MEDLINE
| ID: mdl-29500084
ABSTRACT
BACKGROUND AND PURPOSE:
Ependymoma is the third most common brain tumor in children. Radiation therapy (RT) is systematically administered after maximum surgical resection, utilizing recent advances in radiation delivery. Imaging can make a significant contribution to improving treatment outcome. This prompted us to look for significant preoperative and postoperative imaging markers for survival. MATERIAL ANDMETHODS:
We undertook a national retrospective review of 121 patients who had undergone resection followed by RT. Preoperative tumor volumes on T1 and FLAIR images were delineated, together with postoperative hyperintense volumes on FLAIR images. Overall survival (OS) and disease-free survival (DFS) analyses included clinical data and volumes extracted from images.RESULTS:
After a median follow-up of 38.5â¯months, 80.2% of patients were alive, but 39.7% had experienced at least one event. Statistically significant differences between patients with and without postoperative FLAIR abnormalities were found for both DFS (71.9% vs. 40.3%; pâ¯=â¯0.006) and OS (93.7% vs. 72.4%; pâ¯=â¯0.023) in the univariate analyses, and for OS (pâ¯=â¯0.049) in the multivariate analyses.CONCLUSIONS:
Postoperative FLAIR hyperintensities are a negative prognostic factor for intracranial ependymoma and may be a surrogate for residual disease. They could therefore prove helpful in patients' surgical and radiotherapeutic management.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Encefálicas
/
Ependimoma
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Adolescent
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Adult
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
Idioma:
En
Revista:
Radiother Oncol
Ano de publicação:
2018
Tipo de documento:
Article
País de publicação:
IE
/
IRELAND
/
IRLANDA