Synthesis and SAR study of new hydroxy and chloro-substituted 2,4-diphenyl 5H-chromeno[4,3-b]pyridines as selective topoisomerase II&#945;-targeting anticancer agents.

Magar, Til Bahadur Thapa; Seo, Seung Hee; Kadayat, Tara Man; Jo, Hyunji; Shrestha, Aarajana; Bist, Ganesh; Katila, Pramila; Kwon, Youngjoo; Lee, Eung-Seok

Synthesis and SAR study of new hydroxy and chloro-substituted 2,4-diphenyl 5H-chromeno[4,3-b]pyridines as selective topoisomerase IIα-targeting anticancer agents.

Magar, Til Bahadur Thapa; Seo, Seung Hee; Kadayat, Tara Man; Jo, Hyunji; Shrestha, Aarajana; Bist, Ganesh; Katila, Pramila; Kwon, Youngjoo; Lee, Eung-Seok.

Afiliação

Magar TBT; College of Pharmacy, Yeungnam University, Gyeongsan 38541, Republic of Korea.
Seo SH; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 120-750, Republic of Korea.
Kadayat TM; College of Pharmacy, Yeungnam University, Gyeongsan 38541, Republic of Korea.
Jo H; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 120-750, Republic of Korea.
Shrestha A; College of Pharmacy, Yeungnam University, Gyeongsan 38541, Republic of Korea.
Bist G; College of Pharmacy, Yeungnam University, Gyeongsan 38541, Republic of Korea.
Katila P; College of Pharmacy, Yeungnam University, Gyeongsan 38541, Republic of Korea.
Kwon Y; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 120-750, Republic of Korea. Electronic address: ykwon@ewha.ac.kr.
Lee ES; College of Pharmacy, Yeungnam University, Gyeongsan 38541, Republic of Korea. Electronic address: eslee@yu.ac.kr.

Bioorg Med Chem ; 26(8): 1909-1919, 2018 05 01.

Article em En | MEDLINE | ID: mdl-29510948

Assuntos

Antineoplásicos/síntese química; DNA Topoisomerases Tipo II/metabolismo; Piridinas/química; Inibidores da Topoisomerase II/síntese química; Antineoplásicos/metabolismo; Antineoplásicos/farmacologia; Benzopiranos/química; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; DNA Topoisomerases Tipo II/química; Células HeLa; Humanos; Ligação Proteica; Piridinas/metabolismo; Piridinas/farmacologia; Relação Estrutura-Atividade; Inibidores da Topoisomerase II/metabolismo; Inibidores da Topoisomerase II/farmacologia

Palavras-chave

5H-Chromeno[4,3-b]pyridines; Anticancer agents; Hydroxyl and chlorine-substitution; SAR study; Selective topoisomerase IIα inhibition

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / DNA Topoisomerases Tipo II / Inibidores da Topoisomerase II / Antineoplásicos Limite: Humans Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de publicação: Reino Unido

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