SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL SCREENING OF DIANDRINE A.
Acta Pol Pharm
; 74(3): 873-880, 2017 May.
Article
em En
| MEDLINE
| ID: mdl-29513956
ABSTRACT
Synthesis of a proline-rich cyclic hexapeptide - diandrine A [VI] was accomplished by coupling of tetrapeptide unit Boc-Gly-Pro-Trp-Pro-OH with dipeptide unit Tyr-Phe-OMe followed by cyclization of linear peptide unit [V] under alkaline condition. Structure of newly synthesized cyclopolypeptide was elucidated by means of spectral techniques including FTIR, 'H NMR, "C NMR, MS analyses. VI was subjected to pharmacological screening and found to exhibit good antifungal activity against dermatophytes. Further, VI possessed potent antihelmintic activity against earthworms M. konkanensis, P. corthruses and Eudrilus sp.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligopeptídeos
/
Peptídeos Cíclicos
/
Anti-Helmínticos
/
Antifúngicos
Tipo de estudo:
Diagnostic_studies
/
Screening_studies
Limite:
Animals
Idioma:
En
Revista:
Acta Pol Pharm
Ano de publicação:
2017
Tipo de documento:
Article