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TG/HDL-C ratio and visceral adiposity index may be useful in assessment of insulin resistance in adults with type 1 diabetes in clinical practice.
Uruska, Aleksandra; Zozulinska-Ziolkiewicz, Dorota; Niedzwiecki, Pawel; Pietrzak, Monika; Wierusz-Wysocka, Bogna.
Afiliação
  • Uruska A; Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Poznan, Poland. Electronic address: aleksandrauruska@gmail.com.
  • Zozulinska-Ziolkiewicz D; Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Poznan, Poland.
  • Niedzwiecki P; Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Poznan, Poland.
  • Pietrzak M; Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Poznan, Poland.
  • Wierusz-Wysocka B; Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Poznan, Poland.
J Clin Lipidol ; 12(3): 734-740, 2018.
Article em En | MEDLINE | ID: mdl-29523408
BACKGROUND: Insulin resistance (IR) is an important clinical issue in patients with type 1 diabetes due to worse metabolic control and risk of development of chronic complications. OBJECTIVE: The aim of the study was to evaluate simple and easily available parameters as indirect markers of IR in adults with type 1 diabetes and correlate it with the results of hyperinsulinemic-euglycemic clamp. METHODS: The study included 88 patients (62 men), aged 34.1 ± 6.5 years, with type 1 diabetes with a median disease duration of 8 (7-13) years and mean HbA1c of 7.6 ± 1.5%. Tissue sensitivity to insulin was assessed on the basis of glucose distribution rate (GDR) obtained in the course of hyperinsulinemic-euglycemic clamp. In addition, indirect markers of IR, such as estimated GDR, presence of features of metabolic syndrome, visceral adiposity index (VAI), and the triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio, were evaluated. RESULTS: In the study group, IR defined as GDR <4 mg/kg/min was observed in 33 (37.5%) patients. Group with IR had significantly higher postprandial glycemia (9.1 ± 2.0 vs 8.4 ± 1.1 mmol/L, P = .04), serum TG level (1.11 [0.75-1.92] vs 0.85 [0.60-1.08] mmol/L, P = .001), lower HDL-C level (1.59 ± 0.38 vs 1.8 ± 0.5 mmol/L, P = .02), higher TG/HDL-C ratio (1.60 [1.00-3.13] vs 1.05 [0.62-1.53], P = .001), and higher VAI (2.61 [1.31-4.25] vs 1.56 [0.96-2.25], P = .002). Significant relationship between GDR and TG/HDL-C ratio and VAI, adjusted for age, sex, HbA1c, and duration of diabetes was revealed (respectively, odds ratio 1.90 [95% confidence interval 1.15-3.15], P = .01 and odds ratio 1.47 [95% confidence interval 1.06-2.04], P = .01). CONCLUSIONS: TG/HDL-C ratio and VAI appear to be clinically useful tools to assess IR in adults with type 1 diabetes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triglicerídeos / Resistência à Insulina / Diabetes Mellitus Tipo 1 / Gordura Intra-Abdominal / Adiposidade / HDL-Colesterol Limite: Adult / Female / Humans / Male Idioma: En Revista: J Clin Lipidol Assunto da revista: BIOQUIMICA / METABOLISMO Ano de publicação: 2018 Tipo de documento: Article País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triglicerídeos / Resistência à Insulina / Diabetes Mellitus Tipo 1 / Gordura Intra-Abdominal / Adiposidade / HDL-Colesterol Limite: Adult / Female / Humans / Male Idioma: En Revista: J Clin Lipidol Assunto da revista: BIOQUIMICA / METABOLISMO Ano de publicação: 2018 Tipo de documento: Article País de publicação: Estados Unidos