Role of AMPA glutamate receptors in the conditioned rewarding effects of MDMA in mice.
Behav Brain Res
; 347: 57-60, 2018 07 16.
Article
em En
| MEDLINE
| ID: mdl-29526785
ABSTRACT
Currently, there is not an effective treatment for 3,4-methylenedioxymethamphetamine (MDMA) dependence but pharmacotherapies targeting glutamate neurotransmission are a promising strategy. Previously, we showed that blockade of glutamate NMDA and AMPA receptors impairs the conditioned rewarding effects of MDMA and cocaine, respectively. In this study we evaluated the role of AMPA receptors in the rewarding effects of MDMA in mice using the conditioned place preference (CPP) paradigm. Mice were conditioned with MDMA (1.25â¯mg/kg) 60â¯min after the treatment with saline or different doses (0.25, 1 and 5â¯mg/kg) of the AMPA/kainate receptor antagonist, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX). Mice conditioned with MDMA acquired CPP while those treated with any dose of CNQXâ¯+â¯MDMA did not. These results supported the involvement of the glutamatergic system in the rewarding properties of MDMA, and suggest that AMPA receptor blockade could be a new therapeutic option for the treatment of those individuals that develop MDMA dependence.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Recompensa
/
Receptores de AMPA
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N-Metil-3,4-Metilenodioxianfetamina
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Transtornos Relacionados ao Uso de Anfetaminas
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Alucinógenos
Limite:
Animals
Idioma:
En
Revista:
Behav Brain Res
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Espanha