Validation of the Cut-points Recommended for ROMA Using the Roche Elecsys CA125 and HE4 Assays.
Ann Clin Lab Sci
; 48(1): 90-93, 2018 Jan.
Article
em En
| MEDLINE
| ID: mdl-29531002
ABSTRACT
Assessing the risk of malignancy in patients with a pelvic mass helps triage women suspected of ovarian cancer to specialized gynecologic oncologists to improve treatment outcomes. To this end, several algorithms have been proposed; most notably, the Risk of Ovarian Malignancy Algorithm (ROMA) based on CA125, HE4, and menopausal status. However, appropriate decision cut-points for the ROMA score depends on the choice of analytical assays used. This study validates the use of the Roche Elecsys CA125 and HE4 assays for ROMA calculation in a cohort of 207 women who presented to Mayo Clinic with a pelvic mass. Results were compared to a definitive histologic diagnosis in each case. Clinical performance of ROMA scores derived using these assays was similar to stated claims and indicates that recommended cut-points are acceptable for clinical use.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ovarianas
/
Bioensaio
/
Algoritmos
/
Proteínas
/
Biomarcadores Tumorais
/
Neoplasias Epiteliais e Glandulares
/
Antígeno Ca-125
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
Idioma:
En
Revista:
Ann Clin Lab Sci
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Estados Unidos