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Tumour compartment transcriptomics demonstrates the activation of inflammatory and odontogenic programmes in human adamantinomatous craniopharyngioma and identifies the MAPK/ERK pathway as a novel therapeutic target.
Apps, John R; Carreno, Gabriela; Gonzalez-Meljem, Jose Mario; Haston, Scott; Guiho, Romain; Cooper, Julie E; Manshaei, Saba; Jani, Nital; Hölsken, Annett; Pettorini, Benedetta; Beynon, Robert J; Simpson, Deborah M; Fraser, Helen C; Hong, Ying; Hallang, Shirleen; Stone, Thomas J; Virasami, Alex; Donson, Andrew M; Jones, David; Aquilina, Kristian; Spoudeas, Helen; Joshi, Abhijit R; Grundy, Richard; Storer, Lisa C D; Korbonits, Márta; Hilton, David A; Tossell, Kyoko; Thavaraj, Selvam; Ungless, Mark A; Gil, Jesus; Buslei, Rolf; Hankinson, Todd; Hargrave, Darren; Goding, Colin; Andoniadou, Cynthia L; Brogan, Paul; Jacques, Thomas S; Williams, Hywel J; Martinez-Barbera, Juan Pedro.
Afiliação
  • Apps JR; Developmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, University College London, London, UK. j.apps@ucl.ac.uk.
  • Carreno G; Histopathology Department, Great Ormond Street Hospital NHS Trust, London, UK. j.apps@ucl.ac.uk.
  • Gonzalez-Meljem JM; Developmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.
  • Haston S; Developmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.
  • Guiho R; Basic Research Department, National Institute of Geriatrics, Mexico City, Mexico.
  • Cooper JE; Developmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.
  • Manshaei S; Developmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.
  • Jani N; Developmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.
  • Hölsken A; Developmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.
  • Pettorini B; Centre for Translational Omics-GOSgene, Genetics and Genomic Medicine Programme, UCL Institute of Child Health, University College London, London, UK.
  • Beynon RJ; Department of Neuropathology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.
  • Simpson DM; Alder Hey Children's Hospital NHS Foundation Trust, Liverpool, UK.
  • Fraser HC; Centre for Proteome Research, Institute of Integrative Biology, University of Liverpool, Liverpool, UK.
  • Hong Y; Centre for Proteome Research, Institute of Integrative Biology, University of Liverpool, Liverpool, UK.
  • Hallang S; Developmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.
  • Stone TJ; Infection, Immunity and Inflammation Programme, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.
  • Virasami A; Centre for Craniofacial and Regenerative Biology, King's College London, London, UK.
  • Donson AM; Developmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.
  • Jones D; Histopathology Department, Great Ormond Street Hospital NHS Trust, London, UK.
  • Aquilina K; Histopathology Department, Great Ormond Street Hospital NHS Trust, London, UK.
  • Spoudeas H; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Joshi AR; German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Grundy R; Neurosurgery Department, Great Ormond Street Hospital NHS Trust, London, UK.
  • Storer LCD; Endocrinology Department, Great Ormond Street Hospital NHS Trust, London, UK.
  • Korbonits M; Laboratory Medicine, Royal Victoria Infirmary, Newcastle, UK.
  • Hilton DA; Children's Brain Tumour Research Centre, University of Nottingham, Nottingham, UK.
  • Tossell K; Children's Brain Tumour Research Centre, University of Nottingham, Nottingham, UK.
  • Thavaraj S; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University, London, UK.
  • Ungless MA; Pathology Department, Plymouth Hospitals NHS Trust, Plymouth, UK.
  • Gil J; MRC London Institute of Medical Sciences, Imperial College London, London, UK.
  • Buslei R; Head and Neck Pathology, Dental Institute, King's College London, London, UK.
  • Hankinson T; MRC London Institute of Medical Sciences, Imperial College London, London, UK.
  • Hargrave D; MRC London Institute of Medical Sciences, Imperial College London, London, UK.
  • Goding C; Department of Neuropathology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.
  • Andoniadou CL; Institute of Pathology, Klinikum Sozialstiftung Bamberg, Bamberg, Germany.
  • Brogan P; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Jacques TS; Haematology and Oncology Department, Great Ormond Street Hospital NHS Trust, London, UK.
  • Williams HJ; Ludwig Institute for Cancer Research, Oxford University, Old Road Campus, Headington, Oxford, UK.
  • Martinez-Barbera JP; Centre for Craniofacial and Regenerative Biology, King's College London, Guy's Hospital, Floor 27 Tower Wing, London, UK.
Acta Neuropathol ; 135(5): 757-777, 2018 05.
Article em En | MEDLINE | ID: mdl-29541918
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Hipofisárias / Craniofaringioma / Sistema de Sinalização das MAP Quinases / Microambiente Tumoral / Transcriptoma Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Acta Neuropathol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido País de publicação: Alemanha
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Hipofisárias / Craniofaringioma / Sistema de Sinalização das MAP Quinases / Microambiente Tumoral / Transcriptoma Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Acta Neuropathol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido País de publicação: Alemanha