Antibacterial triterpenoids from the leaves of Ilex hainanensis Merr.
Nat Prod Res
; 33(17): 2435-2439, 2019 Sep.
Article
em En
| MEDLINE
| ID: mdl-29553809
ABSTRACT
One new triterpenoid (1) and seven known analogues (2-8) were isolated from the leaves of Ilex hainanensis Merr.. Their structures were established by analysis of their MS, 1D and 2D NMR spectroscopic data and comparison with those in the literature. The antibacterial activity of compounds 1-8 were evaluated by determination of minimum inhibitory concentration using twofold microdilution broth method against Streptococcus mutans ATCC 25175 (Gram-positive) and Fusobacterium nucleatum ATCC 10953 (Gram-negative). Compounds 3 and 5 showed significant antibacterial activity against S. mutans in concentration of 9.7 µg/mL, while showed little antibacterial activity against F. nucleatum. On the contrary, the inhibitory activity of compounds 1, 2 and 6 against F. nucleatum were higher than them against S. mutans.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Triterpenos
/
Ilex
/
Antibacterianos
Idioma:
En
Revista:
Nat Prod Res
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
China