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Efficacious Vaccine against Heroin Contaminated with Fentanyl.
Hwang, Candy S; Smith, Lauren C; Natori, Yoshihiro; Ellis, Beverly; Zhou, Bin; Janda, Kim D.
Afiliação
  • Hwang CS; Departments of Chemistry, Immunology and Microbial Science, Skaggs Institute for Chemical Biology , The Scripps Research Institute , La Jolla , California 92037 , United States.
  • Smith LC; Departments of Chemistry, Immunology and Microbial Science, Skaggs Institute for Chemical Biology , The Scripps Research Institute , La Jolla , California 92037 , United States.
  • Natori Y; Departments of Chemistry, Immunology and Microbial Science, Skaggs Institute for Chemical Biology , The Scripps Research Institute , La Jolla , California 92037 , United States.
  • Ellis B; Departments of Chemistry, Immunology and Microbial Science, Skaggs Institute for Chemical Biology , The Scripps Research Institute , La Jolla , California 92037 , United States.
  • Zhou B; Departments of Chemistry, Immunology and Microbial Science, Skaggs Institute for Chemical Biology , The Scripps Research Institute , La Jolla , California 92037 , United States.
  • Janda KD; Departments of Chemistry, Immunology and Microbial Science, Skaggs Institute for Chemical Biology , The Scripps Research Institute , La Jolla , California 92037 , United States.
ACS Chem Neurosci ; 9(6): 1269-1275, 2018 06 20.
Article em En | MEDLINE | ID: mdl-29558798
The sharp increase in overdose deaths involving illicit opioid use has been declared a national crisis in the United States. This growing number of overdose deaths can in part be attributed to the increased frequency of fentanyl contamination in the United States heroin supply. To combat this growing trend, we designed a vaccine containing a mixture of heroin and fentanyl hapten-conjugates as a proof-of-concept immunotherapy targeting a combination of these drugs. Rodents immunized with the admixture vaccine showed drug retention in serum and reduced distribution in the brain after administration of an intravenous bolus of heroin coadministered with fentanyl (10% w/w). Moreover, the admixture vaccine performed as well as or better than individual immunoconjugate vaccines in antinociception behavioral models and recognized six other fentanyl analogues with nanomolar affinity. Taken together, these data highlight the potential of an admixture vaccine against heroin contaminated with fentanyl.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinas / Fentanila / Heroína / Transtornos Relacionados ao Uso de Opioides Limite: Animals Idioma: En Revista: ACS Chem Neurosci Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vacinas / Fentanila / Heroína / Transtornos Relacionados ao Uso de Opioides Limite: Animals Idioma: En Revista: ACS Chem Neurosci Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos