Milk Glycans and Their Interaction with the Infant-Gut Microbiota.
Annu Rev Food Sci Technol
; 9: 429-450, 2018 03 25.
Article
em En
| MEDLINE
| ID: mdl-29580136
ABSTRACT
Human milk is a unique and complex fluid that provides infant nutrition and delivers an array of bioactive molecules that serve various functions. Glycans, abundant in milk, can be found as free oligosaccharides or as glycoconjugates. Milk glycans are increasingly linked to beneficial outcomes in neonates through protection from pathogens and modulation of the immune system. Indeed, these glycans influence the development of the infant and the infant-gut microbiota. Bifidobacterium species commonly are enriched in breastfed infants and are among a limited group of bacteria that readily consume human milk oligosaccharides (HMOs) and milk glycoconjugates. Given the importance of bifidobacteria in infant health, numerous studies have examined the molecular mechanisms they employ to consume HMOs and milk glycans, thus providing insight into this unique enrichment and shedding light on a range of translational opportunities to benefit at-risk infants.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polissacarídeos
/
Leite
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Microbioma Gastrointestinal
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Leite Humano
Limite:
Animals
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Humans
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Newborn
Idioma:
En
Revista:
Annu Rev Food Sci Technol
Ano de publicação:
2018
Tipo de documento:
Article