An N-terminally truncated form of cyclic GMP-dependent protein kinase I&#945; (PKG I&#945;) is monomeric and autoinhibited and provides a model for activation.

Moon, Thomas M; Sheehe, Jessica L; Nukareddy, Praveena; Nausch, Lydia W; Wohlfahrt, Jessica; Matthews, Dwight E; Blumenthal, Donald K; Dostmann, Wolfgang R

An N-terminally truncated form of cyclic GMP-dependent protein kinase Iα (PKG Iα) is monomeric and autoinhibited and provides a model for activation.

Moon, Thomas M; Sheehe, Jessica L; Nukareddy, Praveena; Nausch, Lydia W; Wohlfahrt, Jessica; Matthews, Dwight E; Blumenthal, Donald K; Dostmann, Wolfgang R.

Afiliação

Moon TM; Department of Pharmacology, Larner College of Medicine, University of Vermont, Burlington, Vermont 05405. Electronic address: thomasmoon@email.arizona.edu.
Sheehe JL; Department of Pharmacology, Larner College of Medicine, University of Vermont, Burlington, Vermont 05405.
Nukareddy P; Department of Chemistry, University of Vermont, Burlington, Vermont 05405.
Nausch LW; Department of Pharmacology, Larner College of Medicine, University of Vermont, Burlington, Vermont 05405.
Wohlfahrt J; Department of Pharmacology, Larner College of Medicine, University of Vermont, Burlington, Vermont 05405.
Matthews DE; Department of Chemistry, University of Vermont, Burlington, Vermont 05405.
Blumenthal DK; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112.
Dostmann WR; Department of Pharmacology, Larner College of Medicine, University of Vermont, Burlington, Vermont 05405. Electronic address: wolfgang.dostmann@uvm.edu.

J Biol Chem ; 293(21): 7916-7929, 2018 05 25.

Article em En | MEDLINE | ID: mdl-29602907

Assuntos

Proteína Quinase Dependente de GMP Cíclico Tipo I/antagonistas & inibidores; Proteína Quinase Dependente de GMP Cíclico Tipo I/metabolismo; GMP Cíclico/metabolismo; Multimerização Proteica; Sequência de Aminoácidos; Animais; Bovinos; Cristalografia por Raios X; Ativação Enzimática; Humanos; Camundongos; Modelos Moleculares; Fosforilação; Ligação Proteica; Ratos; Espalhamento a Baixo Ângulo; Homologia de Sequência

Palavras-chave

AGC kinases; allosteric regulation; cGMP-dependent protein kinase; cyclic GMP (cGMP); protein kinase; signal transduction; small-angle X-ray scattering (SAXS); surface plasmon resonance (SPR)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: GMP Cíclico / Multimerização Proteica / Proteína Quinase Dependente de GMP Cíclico Tipo I Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2018 Tipo de documento: Article País de publicação: Estados Unidos

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