Human papillomavirus type 16 E5-mediated upregulation of Met in human keratinocytes.
Virology
; 519: 1-11, 2018 06.
Article
em En
| MEDLINE
| ID: mdl-29609071
ABSTRACT
Human papillomaviruses (HPVs) cause benign lesions that can lead to malignancy. How cellular changes induced by viral oncogenes contribute to the progeny virion production is not always clear. Stromally-derived growth factors and their receptors are critical for development of malignancy, but their impact on the pre-malignant HPV life cycle is unknown. We show that HPV16 increases levels of Met, a growth factor receptor critical for tumor cell invasion, motility, and cancer metastasis. The viral oncogene E5 is primarily responsible for Met upregulation, with E6 playing a minor role. Met induction by E5 requires the epidermal growth factor receptor, which is also increased by E5 at the mRNA level. E5-induced Met contributes motility of HPV-containing cells. Finally, Met signaling is necessary for viral gene expression, particularly in the differentiation-dependent phase of the viral life cycle. These studies show a new role for E5 in epithelial-stromal interactions, with implications for cancer development.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Queratinócitos
/
Regulação para Cima
/
Proteínas Oncogênicas Virais
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Proteínas Proto-Oncogênicas c-met
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Papillomavirus Humano 16
Limite:
Humans
Idioma:
En
Revista:
Virology
Ano de publicação:
2018
Tipo de documento:
Article