Pd(II)-Catalyzed Asymmetric Oxidative 1,2-Diamination of Conjugated Dienes with Ureas.

Wu, Min-Song; Fan, Tao; Chen, Shu-Sen; Han, Zhi-Yong; Gong, Liu-Zhu

Wu, Min-Song; Fan, Tao; Chen, Shu-Sen; Han, Zhi-Yong; Gong, Liu-Zhu.

Afiliação

Wu MS; Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry , University of Science and Technology of China , Hefei 230026 , China.
Fan T; Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry , University of Science and Technology of China , Hefei 230026 , China.
Chen SS; Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry , University of Science and Technology of China , Hefei 230026 , China.
Han ZY; Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry , University of Science and Technology of China , Hefei 230026 , China.
Gong LZ; Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry , University of Science and Technology of China , Hefei 230026 , China.

Org Lett ; 20(8): 2485-2489, 2018 04 20.

Article em En | MEDLINE | ID: mdl-29613804

ABSTRACT

ABSTRACT

A palladium(II)-catalyzed asymmetric 1,2-diamination of 1,3-dienes with readily available dialkylureas was established by using a chiral pyridine-oxazoline ligand. The diamination reaction exclusively occurs at the terminal C-C double bond of the 1,3-dienes to give 4-vinylimidazolidin-2-ones in high yields and with excellent levels of enantioselectivity (up to 99% yield, 97% ee). The reaction could feasibly be applied for gram-scale synthesis with a 11 ratio of the diene and the urea.

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Org Lett Assunto da revista: BIOQUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China

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