HCM and DCM cardiomyopathy-linked &#945;-tropomyosin mutations influence off-state stability and crossbridge interaction on thin filaments.

Farman, Gerrie P; Rynkiewicz, Michael J; Orzechowski, Marek; Lehman, William; Moore, Jeffrey R

HCM and DCM cardiomyopathy-linked α-tropomyosin mutations influence off-state stability and crossbridge interaction on thin filaments.

Farman, Gerrie P; Rynkiewicz, Michael J; Orzechowski, Marek; Lehman, William; Moore, Jeffrey R.

Afiliação

Farman GP; Department of Biological Sciences, University of Massachusetts-Lowell, One University Avenue, Lowell, MA 01854, USA; Department of Physiology & Biophysics, Boston University School of Medicine, 700 Albany Street, Boston, MA 02118, USA. Electronic address: gpfarman@email.arizona.edu.
Rynkiewicz MJ; Department of Physiology & Biophysics, Boston University School of Medicine, 700 Albany Street, Boston, MA 02118, USA. Electronic address: rynkiemj@bu.edu.
Orzechowski M; Department of Physiology & Biophysics, Boston University School of Medicine, 700 Albany Street, Boston, MA 02118, USA. Electronic address: morzech@broadinstitute.org.
Lehman W; Department of Physiology & Biophysics, Boston University School of Medicine, 700 Albany Street, Boston, MA 02118, USA. Electronic address: wlehman@bu.edu.
Moore JR; Department of Biological Sciences, University of Massachusetts-Lowell, One University Avenue, Lowell, MA 01854, USA. Electronic address: Jeffrey_Moore@uml.edu.

Arch Biochem Biophys ; 647: 84-92, 2018 06 01.

Article em En | MEDLINE | ID: mdl-29626422

Assuntos

Cardiomiopatias/genética; Miosinas/metabolismo; Mutação Puntual; Tropomiosina/genética; Troponina/metabolismo; Cálcio/metabolismo; Cardiomiopatias/metabolismo; Humanos; Simulação de Dinâmica Molecular; Conformação Proteica; Mapas de Interação de Proteínas; Tropomiosina/química; Tropomiosina/metabolismo

Palavras-chave

Cardiomyopathy; In vitro motility; Molecular dynamics simulations; Muscle regulation; Tropomyosin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tropomiosina / Troponina / Miosinas / Mutação Puntual / Cardiomiopatias Limite: Humans Idioma: En Revista: Arch Biochem Biophys Ano de publicação: 2018 Tipo de documento: Article País de publicação: Estados Unidos

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