Prognostic value of pretreatment plasma D-dimer levels in patients with diffuse large B cell lymphoma (DLBCL).
Clin Chim Acta
; 482: 191-198, 2018 Jul.
Article
em En
| MEDLINE
| ID: mdl-29649456
ABSTRACT
BACKGROUND:
We assessed the prognostic significance of D-dimer in patients of diffuse large B cell lymphoma (DLBCL).METHODS:
We performed a retrospective study including 254 patients who were newly diagnosed DLBCL. X-tile was used to generate a cutoff value for D-dimer. Both univariate screen by Cox proportional hazard model and multivariable analysis by Cox regression model were used to assess the impact of pretreatment D-dimer levels on the overall survival (OS).RESULT:
According to X-tile, the optimal cut-off value of D-dimer for prediction of survival was set as 1.6⯵g/mL, and a D-dimer levelâ¯≥â¯1.6⯵g/mL was significantly associated with poor overall survival (OS) (OS 31.7 vs. 79.1%, Pâ¯<â¯0.001). In multivariable analysis, it was found that a higher D-dimer level was an independent predictor for worse OS (Hazard ratio (HR) 3.594 95% Confidence interval (CI) 2.296-5.267, Pâ¯<â¯0.001). In subgroup analysis of International Prognostic Index (IPI), survival of low-risk and intermediate-risk group with a D-dimer levelâ¯≥â¯1.6⯵g/mL were both similar to that of the high-risk group (OS 31.6 vs. 36.5%, Pâ¯=â¯0.957; OS 38.0 vs. 36.5%, Pâ¯=â¯0.758). In addition, among patients treated with surgery, those with higher D-dimer had substantially worse survival than that with lower D-dimer (OS 27.0 vs. 84.5%, Pâ¯<â¯0.001).CONCLUSION:
Pretreatment D-dimer is a simple but effective predictor of survival among patients with DLBCL.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Produtos de Degradação da Fibrina e do Fibrinogênio
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Linfoma Difuso de Grandes Células B
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Clin Chim Acta
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
China