Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats.
Nutrients
; 10(4)2018 Apr 13.
Article
em En
| MEDLINE
| ID: mdl-29652818
ABSTRACT
BACKGROUND:
we have evaluated the antihypertensive effect of several flavonoid extracts in a rat model of arterial hypertension caused by chronic administration (6 weeks) of the nitric oxide synthesis inhibitor, L-NAME.METHODS:
Sprague Dawley rats received L-NAME alone or L-NAME plus flavonoid-rich vegetal extracts (Lemon, Grapefruit + Bitter Orange, and Cocoa) or purified flavonoids (Apigenin and Diosmin) for 6 weeks.RESULTS:
L-NAME treatment resulted in a marked elevation of blood pressure, and treatment with Apigenin, Lemon Extract, and Grapefruit + Bitter Orange extracts significantly reduced the elevated blood pressure of these animals. Apigenin and some of these flavonoids also ameliorated nitric oxide-dependent and -independent aortic vasodilation and elevated nitrite urinary excretion. End-organ abnormalities such as cardiac infarcts, hyaline arteriopathy and fibrinoid necrosis in coronary arteries and aorta were improved by these treatments, reducing the end-organ vascular damage.CONCLUSIONS:
the flavonoids included in this study, specially apigenin, may be used as functional food ingredients with potential therapeutic benefit in arterial hypertension.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Flavonoides
/
Extratos Vegetais
/
NG-Nitroarginina Metil Éster
/
Hipertensão
/
Rim
/
Anti-Hipertensivos
Limite:
Animals
Idioma:
En
Revista:
Nutrients
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Espanha