Immunotherapy of the nonobese diabetic mouse: treatment with an antibody to T-helper lymphocytes.
Science
; 240(4852): 659-62, 1988 Apr 29.
Article
em En
| MEDLINE
| ID: mdl-2966437
ABSTRACT
Spontaneous diabetes mellitus was blocked in nonobese diabetic mice by treatment with a monoclonal antibody against the L3T4 determinant present on the surface of T-helper lymphocytes. Sustained treatment with the monoclonal antibody led to cessation of the lymphocytic infiltration associated with the destruction of the insulin-producing beta cells. Moreover, the mice remained normoglycemic after the antibody therapy was stopped. These studies indicate that immunotherapy with monoclonal antibodies to the lymphocyte subset may not only halt the progression of diabetes, but may lead to long-term reversal of the disease after therapy has ended.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antígenos de Diferenciação de Linfócitos T
/
Linfócitos T Auxiliares-Indutores
/
Diabetes Mellitus Experimental
/
Imunoterapia
/
Anticorpos Monoclonais
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
1988
Tipo de documento:
Article