Volumetric Brain MRI Study in Fetuses with Congenital Heart Disease.
AJNR Am J Neuroradiol
; 39(6): 1164-1169, 2018 06.
Article
em En
| MEDLINE
| ID: mdl-29674414
ABSTRACT
BACKGROUND AND PURPOSE:
It is well-established that a high prevalence of infants with congenital heart defects surviving to childhood have neurodevelopmental abnormalities. The etiology is not clear. In this study, we aimed to find prenatal neuroanatomic changes in fetuses with congenital heart disease to better understand the pathophysiology behind these sequelae. MATERIALS ANDMETHODS:
A retrospective study of 46 fetal brain MR imaging scans was performed at a tertiary medical center during a 4-year period. Clinical data were collected from electronic medical charts. Volumes of the supratentorial brain, right hemisphere, left hemisphere, and cerebellum were measured using a semiautomated method and were compared with the normal growth percentiles.RESULTS:
We found that cerebellar volume and the cerebellar-supratentorial volume ratio were significantly lower among fetuses with congenital heart disease. Supratentorial and hemisphere volumes showed no difference between groups. This difference was not observed in fetuses with septation defects.CONCLUSIONS:
Fetuses with congenital heart disease have smaller cerebellar volumes than healthy fetuses. Additional research is needed to assess this finding as a radiologic marker for long-term outcome.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Feto
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Cardiopatias Congênitas
Tipo de estudo:
Observational_studies
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Risk_factors_studies
Limite:
Child
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Female
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Humans
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Male
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Pregnancy
Idioma:
En
Revista:
AJNR Am J Neuroradiol
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Israel