Improved therapy for medulloblastoma: targeting hedgehog and PI3K-mTOR signaling pathways in combination with chemotherapy.

Chaturvedi, Nagendra K; Kling, Matthew J; Coulter, Don W; McGuire, Timothy R; Ray, Sutapa; Kesherwani, Varun; Joshi, Shantaram S; Sharp, J Graham

Chaturvedi, Nagendra K; Kling, Matthew J; Coulter, Don W; McGuire, Timothy R; Ray, Sutapa; Kesherwani, Varun; Joshi, Shantaram S; Sharp, J Graham.

Afiliação

Chaturvedi NK; Departments of Pediatrics, Hematology and Oncology, University of Nebraska Medical Center, Omaha, NE 69198, USA.
Kling MJ; Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 69198, USA.
Coulter DW; Departments of Pediatrics, Hematology and Oncology, University of Nebraska Medical Center, Omaha, NE 69198, USA.
McGuire TR; Pharmacy Practice, University of Nebraska Medical Center, Omaha, NE 69198, USA.
Ray S; Departments of Pediatrics, Hematology and Oncology, University of Nebraska Medical Center, Omaha, NE 69198, USA.
Kesherwani V; Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 69198, USA.
Joshi SS; Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 69198, USA.
Sharp JG; Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 69198, USA.

Oncotarget ; 9(24): 16619-16633, 2018 Mar 30.

Article em En | MEDLINE | ID: mdl-29682173

Palavras-chave

MYC; chemotherapy; hedgehog/PI3K-mTOR pathway; medulloblastoma; small molecule inhibitors

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Oncotarget Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos

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