Reproductive and developmental toxicity of potassium perfluorohexanesulfonate in CD-1 mice.
Reprod Toxicol
; 78: 150-168, 2018 06.
Article
em En
| MEDLINE
| ID: mdl-29694846
ABSTRACT
Potassium perfluorohexanesulfonate (K+PFHxS) was evaluated for reproductive/developmental toxicity in CD-1 mice. Up to 3â¯mg/kg-dâ¯K+PFHxS was administered (nâ¯=â¯30/sex/group) before mating, for at least 42â¯days in F0 males, and for F0 females, through gestation and lactation. F1 pups were directly dosed with K+PFHxS for 14â¯days after weaning. There was an equivocal decrease in live litter size at 1 and 3â¯mg/kg-d, but the pup-born-to-implant ratio was unaffected. Adaptive hepatocellular hypertrophy was observed, and in 3â¯mg/kg-d F0 males, it was accompanied by concomitant decreased serum cholesterol and increased alkaline phosphatase. There were no other toxicologically significant findings on reproductive parameters, hematology/clinical pathology/TSH, neurobehavioral effects, or histopathology. There were no treatment-related effects on postnatal survival, development, or onset of preputial separation or vaginal opening in F1 mice. Consistent with previous studies, our data suggest that the potency of PFHxS is much lower than PFOS in rodents.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Efeitos Tardios da Exposição Pré-Natal
/
Ácidos Sulfônicos
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Reprod Toxicol
Assunto da revista:
EMBRIOLOGIA
/
MEDICINA REPRODUTIVA
/
TOXICOLOGIA
Ano de publicação:
2018
Tipo de documento:
Article