Tryptanthrin Protects Mice against Dextran Sulfate Sodium-Induced Colitis through Inhibition of TNF-&#945;/NF-&#954;B and IL-6/STAT3 Pathways.

Wang, Zheng; Wu, Xue; Wang, Cui-Ling; Wang, Li; Sun, Chen; Zhang, Dong-Bo; Liu, Jian-Li; Liang, Yan-Ni; Tang, Dong-Xin; Tang, Zhi-Shu

Tryptanthrin Protects Mice against Dextran Sulfate Sodium-Induced Colitis through Inhibition of TNF-α/NF-κB and IL-6/STAT3 Pathways.

Wang, Zheng; Wu, Xue; Wang, Cui-Ling; Wang, Li; Sun, Chen; Zhang, Dong-Bo; Liu, Jian-Li; Liang, Yan-Ni; Tang, Dong-Xin; Tang, Zhi-Shu.

Afiliação

Wang Z; Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xianyang 712083, China. wazh0405@126.com.
Wu X; Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research, Shaanxi University of Chinese Medicine, Xianyang 712083, China. wazh0405@126.com.
Wang CL; Shaanxi Rheumatism and Tumor Center of TCM Engineering Technology Research, Shaanxi University of Chinese Medicine, Xianyang 712083, China. wazh0405@126.com.
Wang L; Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research, Shaanxi University of Chinese Medicine, Xianyang 712083, China. zhengshangxuew@163.com.
Sun C; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, Xi'an 710069, China. wangcl@nwu.edu.cn.
Zhang DB; Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xianyang 712083, China. 1862927248@163.com.
Liu JL; Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xianyang 712083, China. sunchen2010xian@sina.com.
Liang YN; Shaanxi Rheumatism and Tumor Center of TCM Engineering Technology Research, Shaanxi University of Chinese Medicine, Xianyang 712083, China. 1501009@sntcm.edu.cn.
Tang DX; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, Xi'an 710069, China. jlliu@nwu.edu.cn.
Tang ZS; Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Shaanxi University of Chinese Medicine, Xianyang 712083, China. aiziji_2005@126.com.

Molecules ; 23(5)2018 05 02.

Article em En | MEDLINE | ID: mdl-29724065

Assuntos

Colite; Sulfato de Dextrana/toxicidade; Interleucina-6/metabolismo; NF-kappa B/metabolismo; Quinazolinas/farmacologia; Fator de Transcrição STAT3/metabolismo; Transdução de Sinais/efeitos dos fármacos; Fator de Necrose Tumoral alfa/metabolismo; Animais; Colite/induzido quimicamente; Colite/tratamento farmacológico; Colite/metabolismo; Colite/patologia; Masculino; Camundongos

Palavras-chave

NF-κBp65; STAT3; colitis DSS; tryptanthrin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinazolinas / Transdução de Sinais / Sulfato de Dextrana / NF-kappa B / Interleucina-6 / Fator de Necrose Tumoral alfa / Colite / Fator de Transcrição STAT3 Limite: Animals Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China País de publicação: Suíça

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