A retrospective study of treatment for curative synchronous double primary cancers of the head and neck and the esophagus.
Auris Nasus Larynx
; 45(5): 1053-1060, 2018 Oct.
Article
em En
| MEDLINE
| ID: mdl-29752155
ABSTRACT
OBJECTIVE:
Curative synchronous double primary cancers of the head and neck and the esophagus (CSC-HE) are frequently detected, but a standard treatment remains to be established. We studied the clinical course to explore appropriate treatment strategies.METHODS:
We retrospectively studied consecutive 33 patients who had CSC-HE. The disease stage was classified into 4 groups group A, early head and neck cancer (HNC) and early esophageal cancer (EC); group B, early HNC and advanced EC; group C, advanced HNC and early EC; and group D, advanced HNC and advanced EC. As induction chemotherapy, the patients received 3 courses of TPF therapy (docetaxel 75mg/m2 on day 1, cisplatin 75mg/m2 on day 1, and 5-fluorouracil 750mg/m2 on days 1-5) at 3-week intervals. The clinical courses and treatment outcomes were studied according to the disease stage of CSC-HE.RESULTS:
The disease stage of CSC-HE was group A in 1 patient (3%), group B in 9 patients (27.3%), group C in 3 patients (9.1%), and group D in 20 patients (60.6%). The median follow-up was 26months, and the 2-year overall survival rate was 67.4%. In groups A, B, and C, the 2-year overall survival rate was 83.3%. In group D, the 2-year overall survival rate was 62.6%. Ten of 20 patients in group D received induction chemotherapy with TPF, and 6 patients were alive and disease free at the time of this writing.CONCLUSION:
The treatment outcomes of patients with CSC-HE were relatively good. TPF induction chemotherapy might be an effective treatment for patients with advanced HNC and advanced EC.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Protocolos de Quimioterapia Combinada Antineoplásica
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Quimiorradioterapia
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Carcinoma de Células Escamosas de Cabeça e Pescoço
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Carcinoma de Células Escamosas do Esôfago
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Neoplasias Primárias Múltiplas
Tipo de estudo:
Observational_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Auris Nasus Larynx
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Japão