Genetic alterations crossing the borders of distinct hematopoetic lineages and solid tumors: Diagnostic challenges in the era of high-throughput sequencing in hemato-oncology.

Shumilov, Evgenii; Flach, Johanna; Pabst, Thomas; Fiedler, Martin; Angelillo-Scherrer, Anne; Trümper, Lorenz; Joncourt, Raphael; Kohlmann, Alexander; Bacher, Ulrike

Shumilov, Evgenii; Flach, Johanna; Pabst, Thomas; Fiedler, Martin; Angelillo-Scherrer, Anne; Trümper, Lorenz; Joncourt, Raphael; Kohlmann, Alexander; Bacher, Ulrike.

Afiliação

Shumilov E; Department of Hematology and Clinical Oncology, University Medicine Göttingen (UMG), Göttingen, Germany.
Flach J; Department of Hematology and Clinical Oncology, University Medicine Göttingen (UMG), Göttingen, Germany; Department of Hematology and Oncology, Medical Faculty Mannheim of the Heidelberg University, Mannheim, Germany. Electronic address: johanna.flach@medma.uni-heidelberg.de.
Pabst T; University Department of Oncology, Inselspital, Bern University Hospital, Bern, Switzerland.
Fiedler M; Center of Laboratory Medicine (ZLM)/University Institute of Clinical Chemistry, Inselspital, Bern University Hospital, Bern, Switzerland.
Angelillo-Scherrer A; University Department of Hematology, Inselspital, Bern University Hospital, Bern, Switzerland.
Trümper L; Department of Hematology and Clinical Oncology, University Medicine Göttingen (UMG), Göttingen, Germany.
Joncourt R; University Department of Hematology, Inselspital, Bern University Hospital, Bern, Switzerland.
Kohlmann A; Precision Medicine and Genomics, Innovative Medicines and Early Development, AstraZeneca, Cambridge, United Kingdom.
Bacher U; Center of Laboratory Medicine (ZLM)/University Institute of Clinical Chemistry, Inselspital, Bern University Hospital, Bern, Switzerland; University Department of Hematology, Inselspital, Bern University Hospital, Bern, Switzerland. Electronic address: veraulrike.bacher@insel.ch.

Crit Rev Oncol Hematol ; 126: 64-79, 2018 Jun.

Article em En | MEDLINE | ID: mdl-29759569

Assuntos

Neoplasias Hematológicas/diagnóstico; Neoplasias Hematológicas/genética; Hematopoese/genética; Sequenciamento de Nucleotídeos em Larga Escala; Mutação; Neoplasias/diagnóstico; Neoplasias/genética; Biomarcadores Tumorais/análise; Biomarcadores Tumorais/genética; Linhagem da Célula/genética; Análise Mutacional de DNA/métodos; Análise Mutacional de DNA/normas; Análise Mutacional de DNA/tendências; Neoplasias Hematológicas/patologia; Sequenciamento de Nucleotídeos em Larga Escala/métodos; Sequenciamento de Nucleotídeos em Larga Escala/normas; Sequenciamento de Nucleotídeos em Larga Escala/tendências; Humanos; Prognóstico

Palavras-chave

Clonal hematopoiesis of indeterminate potential (CHIP); Lineage crossover; Modern molecular genetic era; Next-generation sequencing (NGS); Recurrent somatic mutations

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Hematológicas / Sequenciamento de Nucleotídeos em Larga Escala / Hematopoese / Mutação / Neoplasias Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Crit Rev Oncol Hematol Assunto da revista: HEMATOLOGIA / NEOPLASIAS Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Alemanha

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