Inhibition of VEGF gene expression in osteoblast cells by different NSAIDs.
Arch Oral Biol
; 92: 75-78, 2018 Aug.
Article
em En
| MEDLINE
| ID: mdl-29763781
ABSTRACT
OBJECTIVE:
To determine the effect of different nonsteroidal anti-inflammatory drugs (NSAIDs) on vascular endothelial growth factor (VEGF) gene expression in two osteoblast cell populations.DESIGN:
Osteoblasts obtained by primary culture (HOp) and human osteosarcoma cell line MG63 (MG-63), which were treated with 10 µM doses of acetaminophen, indomethacin, ketoprofen, diclofenac, ibuprofen, ketorolac, naproxen or piroxicam. At 24â¯h of treatment, their gene expression of VEGF was evaluated by real-time polymerase chain reaction (RT-PCR) and compared with the expression in untreated cells (control group).RESULTS:
The treatment with the different NSAIDs significantly reduced VEGF expression regardless of the cell line and NSAID studied.CONCLUSION:
The results of this study suggest that these drugs may have undesirable effects on the osteoblast and its bone-forming capacity, given the effect of this growth factor on these cells. Further studies are warranted to determine their repercussions on bone tissue and to elucidate the cell signaling mechanism/s involved.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteoblastos
/
Anti-Inflamatórios não Esteroides
/
Fator A de Crescimento do Endotélio Vascular
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Arch Oral Biol
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Espanha
País de publicação:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM