Reversal of paralysis in nerve-muscle preparations isolated from animals with hereditary motor endplate disease.
Br J Pharmacol
; 84(1): 6-8, 1985 Jan.
Article
em En
| MEDLINE
| ID: mdl-2983805
ABSTRACT
Motor endplate disease (med) in the mouse is an hereditary disorder of the skeletal neuromuscular system. Affected animals suffer a 'functional denervation' of skeletal muscle (Duchen & Stefani, 1971). Muscle fibres do not respond to indirect excitation, but motor nerve terminals release transmitter spontaneously. Spontaneous transmitter release can be enhanced by raising [K+]o or by exposing muscles to red-back spider venom and functional transmission following indirect stimulation may be restored by 4-aminopyridine.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Paralisia
/
Aminopiridinas
/
Placa Motora
/
Doenças Neuromusculares
/
Junção Neuromuscular
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
Br J Pharmacol
Ano de publicação:
1985
Tipo de documento:
Article